Article
Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction.
Circulation. Heart failure - 1 Jul 2012
Weeks Kate L, Gao Xiaoming, Du Xiao-Jun, Boey Esther J H, Matsumoto Aya, Bernardo Bianca C, Kiriazis Helen, Cemerlang Nelly, Tan Joon Win, Tham Yow Keat, Franke Thomas F, Qian Hongwei, Bogoyevitch Marie A, Woodcock Elizabeth A, Febbraio Mark A, Gregorevic Paul, McMullen Julie R
Abstract excerpt
BACKGROUND: Numerous molecular and biochemical changes have been linked with the cardioprotective effects of exercise, including increases in antioxidant enzymes, heat shock proteins, and regulators of cardiac myocyte proliferation. However, a master regulator of exercise-induced protection has yet to be identified. Here, we assess whether phosphoinositide 3-kinase (PI3K) p110α is essential for mediating...
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