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Article

Effects of ageing on pro-arrhythmic ventricular phenotypes in incrementally paced murine Pgc-1β -/- hearts.

Pflugers Archiv : European journal of physiology - 1 Dec 2017

Ahmad Shiraz, Valli Haseeb, Edling Charlotte E, Grace Andrew A, Jeevaratnam Kamalan, Huang Christopher L-H

Abstract excerpt

A range of chronic clinical conditions accompany cardiomyocyte energetic dysfunction and constitute independent risk factors for cardiac arrhythmia. We investigated pro-arrhythmic and arrhythmic phenotypes in energetically deficient C57BL mice with genetic ablation of the mitochondrial promoter peroxisome proliferator-activated receptor-γ coactivator-1β (Pgc-1β), a known model of ventricular arrhythmia....

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Source

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Identifiers

PMID: 28821956
DOI: 10.1007/s00424-017-2054-3
PMCID: PMC5691113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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