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Article

Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart.

Cardiovascular research - 1 Aug 2010

Webb Ian G, Nishino Yasuhiro, Clark James E, Murdoch Colin, Walker Simon J, Makowski Marcus R, Botnar Rene M, Redwood Simon R, Shah Ajay M, Marber Michael S

Abstract excerpt

AIMS: Glycogen synthase kinase 3 (GSK-3) signalling is implicated in the growth of the heart during development and in response to stress. However, its precise role remains unclear. We set out to characterize developmental growth and response to chronic isoproterenol (ISO) stress in knockin (KI) mice lacking the critical N-terminal serines, 21 of GSK-3alpha and 9 of GSK-3beta respectively, required for...

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Source

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Identifiers

PMID: 20299330
DOI: 10.1093/cvr/cvq061
PMCID: PMC2904659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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