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Article

DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features.

Blood - 19 Mar 2015

Arribas Alberto J, Rinaldi Andrea, Mensah Afua A, Kwee Ivo, Cascione Luciano, Robles Eloy F, Martinez-Climent Jose A, Oscier David, Arcaini Luca, Baldini Luca, Marasca Roberto, Thieblemont Catherine, Briere Josette, Forconi Francesco, Zamò Alberto, Bonifacio Massimiliano, Mollejo Manuela, Facchetti Fabio, Dirnhofer Stephan, Ponzoni Maurilio, Bhagat Govind, Piris Miguel A, Gaidano Gianluca, Zucca Emanuele, Rossi Davide, Bertoni Francesco

Abstract excerpt

Splenic marginal zone lymphoma is a rare lymphoma. Loss of 7q31 and somatic mutations affecting the NOTCH2 and KLF2 genes are the commonest genomic aberrations. Epigenetic changes can be pharmacologically reverted; therefore, identification of groups of patients with specific epigenomic alterations might have therapeutic relevance. Here we integrated genome-wide DNA-promoter methylation profiling with gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, B-Cell, Marginal Zone

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Source

Open in PubMed Open full text

Identifiers

PMID: 25612624
DOI: 10.1182/blood-2014-08-596247
PMCID: PMC4416938

Genes

NOTCH2
CACNB2
HTRA1
KLF2
KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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