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Article

Splenic marginal zone lymphoma: from genetics to management.

Blood - 28 Apr 2016

Arcaini Luca, Rossi Davide, Paulli Marco

Abstract excerpt

Splenic marginal zone lymphoma (SMZL) is a rare B-cell malignancy involving the spleen, bone marrow, and frequently the blood. SMZL lymphomagenesis involves antigen and/or superantigen stimulation and molecular deregulation of genes (NOTCH2 and KLF2) involved in the physiological differentiation of spleen marginal zone B cells. Diagnosis requires either spleen histology or, alternatively, the documentation of a...

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Source

Identifiers

PMID: 26989207
DOI: 10.1182/blood-2015-11-624312

Genes

NOTCH2
KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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