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Article

Splenic marginal zone lymphoma: from genetics to management.

Blood - 28 Apr 2016

Arcaini Luca, Rossi Davide, Paulli Marco

Abstract excerpt

Splenic marginal zone lymphoma (SMZL) is a rare B-cell malignancy involving the spleen, bone marrow, and frequently the blood. SMZL lymphomagenesis involves antigen and/or superantigen stimulation and molecular deregulation of genes (NOTCH2 and KLF2) involved in the physiological differentiation of spleen marginal zone B cells. Diagnosis requires either spleen histology or, alternatively, the documentation of a...

Topics

Antineoplastic Combined Chemotherapy Protocols
Antiviral Agents
Autoimmune Diseases
Cell Transformation, Neoplastic
Combined Modality Therapy
Diagnosis, Differential
Disease Management
Hepatitis C, Chronic
Humans
Kruppel-Like Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, B-Cell, Marginal Zone

Mutation

Neoplasm Proteins

Paraneoplastic Syndromes

Prognosis

Receptor, Notch2

Splenectomy

Splenic Neoplasms

Source

Identifiers

PMID: 26989207
DOI: 10.1182/blood-2015-11-624312

Genes

NOTCH2
KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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