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Article

NOTCH signaling in the pathogenesis of splenic marginal zone lymphoma-opportunities for therapy.

Leukemia & lymphoma - 1 Feb 2022

Alderuccio Juan Pablo, Lossos Izidore S

Abstract excerpt

NOTCH signaling is a highly conserved pathway mediated by four receptors (NOTCH 1-4) playing critical functions in proliferation, differentiation, and cell death. Under physiologic circumstances, NOTCH2 is a key regulator in marginal zone differentiation and development. Over the last decade, growing data demonstrated frequent NOTCH2 mutations in splenic marginal zone lymphoma (SMZL) underscoring its critical...

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Share to Leukemia, Lymphocytic, Chronic, B-Cell
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Share to Lymphoma, B-Cell, Marginal Zone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34586000
DOI: 10.1080/10428194.2021.1984452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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