Article
Splenic marginal-zone lymphoma: ontogeny and genetics.
Leukemia & lymphoma - 1 Feb 2015
Baliakas Panagiotis, Strefford Jonathan C, Bikos Vasilis, Parry Marina, Stamatopoulos Kostas, Oscier David
Abstract excerpt
Splenic marginal-zone lymphoma (SMZL) is a rare tumor that has recently emerged as a prototype for how the interplay between genetics and environment shapes the natural history of lymphomas. Indeed, the recent identification of molecular immunogenetic subgroups within SMZL may prove to be relevant not only for the sub-classification of the disease but also for improved understanding of the underlying biology. In...
Topics
- B-Lymphocytes
- Chromosome Aberrations
- DNA Copy Number Variations
- Genetic Predisposition to Disease
- Humans
- Lymphoma, B-Cell, Marginal Zone
- Mutation
- Signal Transduction
- Splenic Neoplasms