Article
Whole-exome sequencing in splenic marginal zone lymphoma reveals mutations in genes involved in marginal zone differentiation.
Leukemia - 1 Jun 2014
Martínez N, Almaraz C, Vaqué J P, Varela I, Derdak S, Beltran S, Mollejo M, Campos-Martin Y, Agueda L, Rinaldi A, Kwee I, Gut M, Blanc J, Oscier D, Strefford J C, Martinez-Lopez J, Salar A, Sole F, Rodriguez-Peralto J L, Diez-Tascón C, García J F, Fraga M, Sebastián E, Alvés J, Menárguez J, González-Carreró J, Casado L F, Bayes M, Bertoni F, Gut I, Piris M A
Abstract excerpt
Splenic marginal zone lymphoma (SMZL) is a B-cell neoplasm whose molecular pathogenesis remains fundamentally unexplained, requiring more precise diagnostic markers. Previous molecular studies have revealed 7q loss and mutations of nuclear factor κB (NF-κB), B-cell receptor (BCR) and Notch signalling genes. We performed whole-exome sequencing in a series of SMZL cases. Results confirmed that SMZL is an entity...
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