Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing.

doi:10.1158/1078-0432.CCR-14-2759

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Article

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2015

Parry Marina, Rose-Zerilli Matthew Jj, Ljungström Viktor, Gibson Jane, Wang Jun, Walewska Renata, Parker Helen, Parker Anton, Davis Zadie, Gardiner Anne, McIver-Brown Neil, Kalpadakis Christina, Xochelli Aliki, Anagnostopoulos Achilles, Fazi Claudia, de Castro David Gonzalez, Dearden Claire, Pratt Guy, Rosenquist Richard, Ashton-Key Margaret, Forconi Francesco, Collins Andrew, Ghia Paolo, Matutes Estella, Pangalis Gerassimos, Stamatopoulos Kostas, Oscier David, Strefford Jonathan C

Abstract excerpt

PURPOSE: Mounting evidence supports the clinical significance of gene mutations and immunogenetic features in common mature B-cell malignancies. EXPERIMENTAL DESIGN: We undertook a detailed characterization of the genetic background of splenic marginal zone lymphoma (SMZL), using targeted resequencing and explored potential clinical implications in a multinational cohort of 175 patients with SMZL. RESULTS: We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25779943
DOI: 10.1158/1078-0432.CCR-14-2759
PMCID: PMC4490180

Genes

NOTCH2
KLF2
MYD88
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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