Article
Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.
PloS one - 1 Jan 2013
Parry Marina, Rose-Zerilli Matthew J J, Gibson Jane, Ennis Sarah, Walewska Renata, Forster Jade, Parker Helen, Davis Zadie, Gardiner Anne, Collins Andrew, Oscier David G, Strefford Jonathan C
Abstract excerpt
The pathogenesis of splenic marginal zone lymphoma (SMZL) remains largely unknown. Recent high-throughput sequencing studies have identified recurrent mutations in key pathways, most notably NOTCH2 mutations in >25% of patients. These studies are based on small, heterogeneous discovery cohorts, and therefore only captured a fraction of the lesions present in the SMZL genome. To identify further novel pathogenic...
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