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Article

New strategies in myelodysplastic syndromes: application of molecular diagnostics to clinical practice.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2013

Tothova Zuzana, Steensma David P, Ebert Benjamin L

Abstract excerpt

An increasingly complete compendium of recurrently mutated genes in myelodysplastic syndromes (MDS) has been defined, and the application of massively parallel sequencing to identify mutations in clinical practice now promises to improve the care of patients with this disease. More than 25 recurrent MDS-associated somatic mutations have been identified, involving biologic pathways as diverse as chromatin...

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Identifiers

PMID: 23329810
DOI: 10.1158/1078-0432.CCR-12-1251
PMCID: PMC3748432

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