Article
The Molecular Floodgates of Stress-Induced Senescence Reveal Translation, Signalling and Protein Activity Central to the Post-Mortem Proteome.
International journal of molecular sciences - 3 Sept 2020
Wasinger Valerie C, Curnoe Darren, Boel Ceridwen, Machin Naomi, Goh Hsiao Mei
Abstract excerpt
The transitioning of cells during the systemic demise of an organism is poorly understood. Here, we present evidence that organismal death is accompanied by a common and sequential molecular flood of stress-induced events that propagate the senescence phenotype, and this phenotype is preserved in the proteome after death. We demonstrate activation of "death" pathways involvement in diseases of ageing, with...
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