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p21 Ablation in Liver Enhances DNA Damage, Cholestasis, and Carcinogenesis

22 Jan 2015

Abstract excerpt

Genetic mouse studies suggest that the NF-κB pathway regulator NEMO (also known as IKKγ) controls chronic inflammation and carcinogenesis in the liver. However, the molecular mechanisms explaining the function of NEMO are not well defined. Here, we report that overexpression of the cell-cycle regulator p21 is a critical feature of liver inflammation and carcinogenesis caused by the loss of NEMO. NEMO(Δhepa) mice...

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PMID: 25608711
DOI: 10.1158/0008-5472.can-14-1356

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