Article
NF-κB essential modifier is required for hepatocyte proliferation and the oval cell reaction after partial hepatectomy in mice.
Gastroenterology - 1 Dec 2012
Malato Yann, Ehedego Haksier, Al-Masaoudi Malika, Cubero Francisco Javier, Bornemann Jörn, Gassler Nikolaus, Liedtke Christian, Beraza Naiara, Trautwein Christian
Abstract excerpt
BACKGROUND & AIMS: The transcription factor nuclear factor κB (NF-κB) is activated by the IκB kinase complex. The regulatory subunit of this complex, NF-κB essential modifier (NEMO or IKBKG), is a tumor suppressor. Hepatocyte-specific deletion of NEMO induces chronic liver inflammation that leads to apoptosis, oxidative stress, development of nonalcoholic steatohepatitis, and hepatocarcinogenesis. METHODS: We...
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