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Article

The Cdk inhibitor p21 is required for necrosis, but it inhibits apoptosis following toxin-induced liver injury.

The Journal of biological chemistry - 8 Aug 2003

Kwon Young Hye, Jovanovic Aleksandra, Serfas Michael S, Tyner Angela L

Abstract excerpt

Liver injury and repair were examined in wild type, p21Waf1/Cip1, and p27Kip1-deficient mice following carbon tetrachloride (CCl4) administration. In wild type liver, p21 expression is induced in a biphasic manner following injection of CCl4, with an early peak of p21 expression occurring in peri...

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Source

Identifiers

PMID: 12759355
DOI: 10.1074/jbc.M300996200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12759355-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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