Article
The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove.
Cell - 15 Oct 2010
Stefl Richard, Oberstrass Florian C, Hood Jennifer L, Jourdan Muriel, Zimmermann Michal, Skrisovska Lenka, Maris Christophe, Peng Li, Hofr Ctirad, Emeson Ronald B, Allain Frédéric H-T
Abstract excerpt
Sequence-dependent recognition of dsDNA-binding proteins is well understood, yet sequence-specific recognition of dsRNA by proteins remains largely unknown, despite their importance in RNA maturation pathways. Adenosine deaminases that act on RNA (ADARs) recode genomic information by the site-selective deamination of adenosine. Here, we report the solution structure of the ADAR2 double-stranded RNA-binding motifs...
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