Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.

Nature communications - 21 Jan 2015

Yu Jiayi, Zhou Xiaofei, Chang Mikyoung, Nakaya Mako, Chang Jae-Hoon, Xiao Yichuan, Lindsey J William, Dorta-Estremera Stephanie, Cao Wei, Zal Anna, Zal Tomasz, Sun Shao-Cong

Abstract excerpt

Development of an immune or autoimmune response involves T-cell activation in lymphoid organs and subsequent migration to peripheral tissues. Here we show that T-cell-specific ablation of the kinase TBK1 promotes T-cell activation but causes retention of effector T cells in the draining lymph node in a neuroinflammatory autoimmunity model, experimental autoimmune encephalomyelitis (EAE). At older ages, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmunity
Share to Central Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Jurkat Cells

Share to Mechanistic Target of Rapamycin Complex 1

Share to Multiprotein Complexes

Share to Orthomyxoviridae

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 25606824
DOI: 10.1038/ncomms7074
PMCID: PMC4302769

Genes

TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.PMID 25606824Read ↗

TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and diseaseSemantic proximity Read ↗

Human TBK1: A Gatekeeper of Neuroinflammation.Semantic proximity Read ↗

Roles for the IKK-Related Kinases TBK1 and IKKε in CancerSemantic proximity Read ↗

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1.Semantic proximity Read ↗

TBK1: a new player in ALS linking autophagy and neuroinflammationSemantic proximity Read ↗

Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in miceSemantic proximity Read ↗

A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.Semantic proximity Read ↗

Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling.Semantic proximity Read ↗

The AKT Axis as a Therapeutic Target in Autoimmune DiseasesSemantic proximity Read ↗

LCK at the crossroad of immunodeficiency and autoimmunity: Mechanisms and therapeutic opportunities.Semantic proximity Read ↗

Targeted Deletion of Integrin-Linked Kinase Reveals a Role in T-Cell Chemotaxis and SurvivalSemantic proximity Read ↗

LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.