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Article

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1.

Cell - 6 Sept 2018

Yu Haiyang, Cleveland Don W

Abstract excerpt

Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together cause neuroinflammation.

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Source

Identifiers

PMID: 30193106
DOI: 10.1016/j.cell.2018.08.035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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