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Article

TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease

14 Jan 2021

Abstract excerpt

TANK-binding kinase 1 (TBK1) is a druggable multifunctional kinase that exerts a broad spectrum of functions in cells. These range from innate immunity, inflammation and interferon (IFN) signaling, through selective autophagy, specifically mitophagy and xenophagy, to energy homeostasis. Thus, it is not surprising that TBK1 is involved in many cellular signaling pathways that contribute to diverse pathologies. In...

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PMID: 33454423
DOI: 10.1016/j.matbio.2021.01.004

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