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Article

Dissecting the mechanisms of Notch induced hyperplasia.

The EMBO journal - 9 Jan 2013

Djiane Alexandre, Krejci Alena, Bernard Frédéric, Fexova Silvie, Millen Katherine, Bray Sarah J

Abstract excerpt

The outcome of the Notch pathway on proliferation depends on cellular context, being growth promotion in some, including several cancers, and growth inhibition in others. Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms, we have used genomic strategies to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23232763
DOI: 10.1038/emboj.2012.326
PMCID: PMC3545308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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