Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states.

eLife - 25 Sept 2014

LeBon Lauren, Lee Tom V, Sprinzak David, Jafar-Nejad Hamed, Elowitz Michael B

Abstract excerpt

The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control the specificity and directionality of Notch signaling in developmental contexts. Here, we analyzed same-cell (cis) Notch-ligand interactions for Notch1, Dll1, and Jag1, and their dependence on Fringe protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Binding Proteins
Share to Cricetulus
Share to Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Jagged-1 Protein

Share to N-Acetylglucosaminyltransferases

Share to Receptors, Notch

Share to Serrate-Jagged Proteins

Share to Wings, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 25255098
DOI: 10.7554/eLife.02950
PMCID: PMC4174579

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states.PMID 25255098Read ↗

Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype.Semantic proximity Read ↗

Fringe forms a complex with Notch.Semantic proximity Read ↗

Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation.Semantic proximity Read ↗

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.Semantic proximity Read ↗

fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.Semantic proximity Read ↗

Notch signaling: control of cell communication and cell fate.Semantic proximity Read ↗

In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe.Semantic proximity Read ↗

Notch -- a goldilocks signaling pathway in disease and cancer therapy.Semantic proximity Read ↗

Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing.Semantic proximity Read ↗

Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila.Semantic proximity Read ↗

Interactions between wingless and frizzled molecules in Drosophila.Semantic proximity Read ↗

Cross regulation of intercellular gap junction communication and paracrine signaling pathways during organogenesis in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.