Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic contribution of catechol-O-methyltransferase in hippocampal structural and functional changes of female migraine sufferers.

Human brain mapping - 1 May 2015

Liu Jixin, Lan Lei, Mu Junya, Zhao Ling, Yuan Kai, Zhang Yi, Huang Liyu, Liang Fanrong, Tian Jie

Abstract excerpt

Physiological and emotional stressors are associated with or provoke each migraine attack and cause structural and functional changes in the central nervous system. The hippocampus, a limbic structure important in anxiety-related behavior, is vulnerable to long-term stress. Given that catechol-O-methyltransferase (COMT) is widely distributed in the hippocampus and its genetic variation is thought to contribute to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Brain Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Gray Matter

Share to Migraine without Aura

Share to Neural Pathways

Share to Psychiatric Status Rating Scales

Source

Open in PubMed Open full text

Identifiers

PMID: 25598522
DOI: 10.1002/hbm.22737
PMCID: PMC6869255

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic contribution of catechol-O-methyltransferase in hippocampal structural and functional changes of female migraine sufferers.PMID 25598522Read ↗

The importance of identifying functional Val158Met polymorphism in catechol-O- Methyltransferase when assessing MRI-based volumetric measurements in major depressive disorder.Semantic proximity Read ↗

Imaging genomics applied to anxiety, stress response, and resiliency.Semantic proximity Read ↗

Impact of catechol-O-methyltransferase Val(108/158) Met genotype on hippocampal and prefrontal gray matter volume.Semantic proximity Read ↗

The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity in patients with panic disorder.Semantic proximity Read ↗

Genetic Variation in the Catechol-O-Methyl Transferase Val108/158Met Is Linked to the Caudate and Posterior Cingulate Cortex Volume in Healthy Subjects: Voxel-Based Morphometry Analysis of Brain Magnetic Resonance Imaging.Semantic proximity Read ↗

Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.Semantic proximity Read ↗

The COMT val158met polymorphism and brain morphometry in healthy young adults.Semantic proximity Read ↗

Female-specific effects of the catechol-O-methyl transferase Val158Met gene polymorphism on working memory-related brain function.Semantic proximity Read ↗

Neuroprotective effect of Val variant of BDNF Val66Met polymorphism on hippocampus is modulated by the severity of menstrual pain.Semantic proximity Read ↗

Elucidating the relationship between migraine risk and brain structure using genetic data.Semantic proximity Read ↗

Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: Voxel-based morphometry analysis.Semantic proximity Read ↗

Stress-related methylation of the catechol-O-methyltransferase Val 158 allele predicts human prefrontal cognition and activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.