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Article

Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses.

International journal of cancer - 15 Jun 2007

Lissowska Jolanta, Gaudet Mia M, Brinton Louise A, Chanock Stephen J, Peplonska Beata, Welch Robert, Zatonski Witold, Szeszenia-Dabrowska Neonila, Park Sue, Sherman Mark, Garcia-Closas Montserrat

Abstract excerpt

Epidemiological evidence suggests that intake of folate and other B-vitamins and genetic variants in the one-carbon metabolism pathway could influence the risk of breast cancer. Previous studies have focused on 2 polymorphisms in the methylenetetrahydrofolate gene (MTHFR A222V and E429A); however, findings are inconclusive. In a large population-based case-control study in Poland (2,386 cases, 2,502 controls), we...

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Source

Identifiers

PMID: 17311260
DOI: 10.1002/ijc.22604

Genes

MTHFR
MTR
CBS
MTRR
SHMT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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