Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review.

doi:10.1038/tpj.2009.29

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Article

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review.

The pharmacogenomics journal - 1 Oct 2009

Carr D F, Whiteley G, Alfirevic A, Pirmohamed M

Abstract excerpt

Genetic polymorphisms in the one-carbon folate pathway have been widely studied in association with a number of conditions. Most of the research has focused on the 677C>T polymorphism in the coding region of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. However, there are a total of 25 genes in this pathway coding for enzymes, transporters and receptors, which can be investigated using 267 tagging...

Topics

Animals
Computational Biology
Databases, Genetic
Epigenesis, Genetic
Folic Acid
Gene Frequency
Genetic Predisposition to Disease
Genetics, Population
Humans
Hyperhomocysteinemia
Metabolomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylenetetrahydrofolate Reductase (NADPH2)

Mice

Mice, Transgenic

Models, Animal

Pharmacogenetics

Phenotype

Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 19581920
DOI: 10.1038/tpj.2009.29

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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