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Article

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review.

The pharmacogenomics journal - 1 Oct 2009

Carr D F, Whiteley G, Alfirevic A, Pirmohamed M

Abstract excerpt

Genetic polymorphisms in the one-carbon folate pathway have been widely studied in association with a number of conditions. Most of the research has focused on the 677C>T polymorphism in the coding region of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. However, there are a total of 25 genes in this pathway coding for enzymes, transporters and receptors, which can be investigated using 267 tagging...

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Source

Identifiers

PMID: 19581920
DOI: 10.1038/tpj.2009.29

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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