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Article

ABC50 mutants modify translation start codon selection.

The Biochemical journal - 15 Apr 2015

Stewart Joanna D, Cowan Joanne L, Perry Lisa S, Coldwell Mark J, Proud Christopher G

Abstract excerpt

ATP-binding cassette 50 (ABC50; also known as ABCF1) binds to eukaryotic initiation factor 2 (eIF2) and is required for efficient translation initiation. An essential step of this process is accurate recognition and selection of the initiation codon. It is widely accepted that the presence and movement of eIF1, eIF1A and eIF5 are key factors in modulating the stringency of start-site selection, which normally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25597744
DOI: 10.1042/BJ20141453

Genes

ABCF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ABC50 mutants modify translation start codon selection.PMID 25597744Read ↗

ABC50 promotes translation initiation in mammalian cells.Semantic proximity Read ↗

Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.Semantic proximity Read ↗

The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo.Semantic proximity Read ↗

eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning.Semantic proximity Read ↗

Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codons.Semantic proximity Read ↗

The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection.Semantic proximity Read ↗

Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.Semantic proximity Read ↗

Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery.Semantic proximity Read ↗

The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.Semantic proximity Read ↗

Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode.Semantic proximity Read ↗

Defect in the GTPase activating protein (GAP) function of eIF5 causes repression of GCN4 translation.Semantic proximity Read ↗

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