Article
The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection.
Molecular and cellular biology - 1 Aug 2003
He Hui, von der Haar Tobias, Singh C Ranjit, Ii Miki, Li Bin, Hinnebusch Alan G, McCarthy John E G, Asano Katsura
Abstract excerpt
Eukaryotic initiation factor 4G (eIF4G) promotes mRNA recruitment to the ribosome by binding to the mRNA cap- and poly(A) tail-binding proteins eIF4E and Pap1p. eIF4G also binds eIF4A at a distinct HEAT domain composed of five stacks of antiparallel alpha-helices. The role of eIF4G in the later steps of initiation, such as scanning and AUG recognition, has not been defined. Here we show that the entire HEAT...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.