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Article

Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codons.

Molecular and cellular biology - 1 Dec 2011

Martin-Marcos Pilar, Cheung Yuen-Nei, Hinnebusch Alan G

Abstract excerpt

Yeast eIF1 inhibits initiation at non-AUG triplets, but it was unknown whether it also discriminates against AUGs in suboptimal context. As in other eukaryotes, the yeast gene encoding eIF1 (SUI1) contains an AUG in poor context, which could underlie translational autoregulation. Previously, eIF1 mutations were identified that increase initiation at UUG codons (Sui(-) phenotype), and we obtained mutations with...

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Identifiers

PMID: 21930786
DOI: 10.1128/MCB.05819-11
PMCID: PMC3232919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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