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Article

Eukaryotic translation initiation factor 5 is critical for integrity of the scanning preinitiation complex and accurate control of GCN4 translation.

Molecular and cellular biology - 1 Jul 2005

Singh Chingakham Ranjit, Curtis Cynthia, Yamamoto Yasufumi, Hall Nathan S, Kruse Dustin S, He Hui, Hannig Ernest M, Asano Katsura

Abstract excerpt

The integrity of eukaryotic translation initiation factor (eIF) interactions in ribosomal pre-initiation complexes is critical for the proper regulation of GCN4 mRNA translation in response to amino acid availability. Increased phosphorylation of eIF2 under amino acid starvation conditions leads...

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PMID: 15964804
DOI: 10.1128/MCB.25.13.5480-5491.2005
PMCID: PMC1156968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15964804-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Eukaryotic translation initiation factor 5 is critical for integrity of the scanning preinitiation complex and accurate control of GCN4 translation.PMID 15964804Read ↗

Isolation and functional characterization of a temperature-sensitive mutant of the yeast Saccharomyces cerevisiae in translation initiation factor eIF5: an eIF5-dependent cell-free translation system.Semantic proximity Read ↗

Defect in the GTPase activating protein (GAP) function of eIF5 causes repression of GCN4 translation.Semantic proximity Read ↗

The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo.Semantic proximity Read ↗

Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.Semantic proximity Read ↗

The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection.Semantic proximity Read ↗

The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.Semantic proximity Read ↗

Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.Semantic proximity Read ↗

Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.Semantic proximity Read ↗

Structural modeling and mutational analysis of yeast eukaryotic translation initiation factor 5A reveal new critical residues and reinforce its involvement in protein synthesis.Semantic proximity Read ↗

eIF5A is an indispensable protein for eukaryotic cellsSemantic proximity Read ↗

Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode.Semantic proximity Read ↗

The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G.Semantic proximity Read ↗

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