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Article

ABC50 promotes translation initiation in mammalian cells.

The Journal of biological chemistry - 4 Sept 2009

Paytubi Sonia, Wang Xuemin, Lam Yun W, Izquierdo Luis, Hunter Mairi J, Jan Eric, Hundal Harinder S, Proud Christopher G

Abstract excerpt

ABC50 is an ATP-binding cassette (ABC) protein, which, unlike most ABC proteins, does not possess membrane-spanning domains. ABC50 interacts with eukaryotic initiation factor 2 (eIF2), which plays a key role in translation initiation and its control. ABC50 binds to ribosomes, and this interaction requires both the N-terminal domain and at least one ABC domain. Knockdown of ABC50 by RNA interference impaired...

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Share to Amino Acid Motifs
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eukaryotic Initiation Factor-2

Share to Peptide Chain Initiation, Translational

Share to Protein Structure, Tertiary

Share to Ribosomes

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Source

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Identifiers

PMID: 19570978
DOI: 10.1074/jbc.M109.031625
PMCID: PMC2782000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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