A genetic risk score is associated with hepatic triglyceride content and non-alcoholic steatohepatitis in Mexicans with morbid obesity.

doi:10.1016/j.yexmp.2015.01.012

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Article

A genetic risk score is associated with hepatic triglyceride content and non-alcoholic steatohepatitis in Mexicans with morbid obesity.

Experimental and molecular pathology - 1 Apr 2015

León-Mimila Paola, Vega-Badillo Joel, Gutiérrez-Vidal Roxana, Villamil-Ramírez Hugo, Villareal-Molina Teresa, Larrieta-Carrasco Elena, López-Contreras Blanca E, Kauffer Luis R Macías, Maldonado-Pintado Diana G, Méndez-Sánchez Nahúm, Tovar Armando R, Hernández-Pando Rogelio, Velázquez-Cruz Rafael, Campos-Pérez Francisco, Aguilar-Salinas Carlos A, Canizales-Quinteros Samuel

Abstract excerpt

BACKGROUND AND AIMS: Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near/in PNPLA3, NCAN, LYPLAL1, PPP1R3B, and GCKR genes associated with non-alcoholic fatty liver disease (NAFLD) mainly in individuals of European ancestry. The aim of the study was to test whether these genetic variants and a genetic risk score (GRS) are associated with elevated liver fat content and...

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Identifiers

PMID: 25597287
DOI: 10.1016/j.yexmp.2015.01.012

Genes

GCKR
LYPLAL1
PNPLA3
NCAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A genetic risk score is associated with hepatic triglyceride content and non-alcoholic steatohepatitis in Mexicans with morbid obesity.PMID 25597287Read ↗

Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.Semantic proximity Read ↗

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.Semantic proximity Read ↗

Genetic variants in COL13A1, ADIPOQ and SAMM50, in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population.Semantic proximity Read ↗

Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity.Semantic proximity Read ↗

Association between variants in or near PNPLA3, GCKR, and PPP1R3B with ultrasound-defined steatosis based on data from the third National Health and Nutrition Examination Survey.Semantic proximity Read ↗

A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease.Semantic proximity Read ↗

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