Article
Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity.
Human heredity - 1 Jan 2013
Gorden Alexis, Yang Rongze, Yerges-Armstrong Laura M, Ryan Kathleen A, Speliotes Elizabeth, Borecki Ingrid B, Harris Tamara B, Chu Xin, Wood G Craig, Still Christopher D, Shuldiner Alan R, Gerhard Glenn S
Abstract excerpt
OBJECTIVE: Obesity-associated non-alcoholic fatty liver disease (NAFLD) may cause liver dysfunction and failure. In a previously reported genome-wide association meta-analysis, single nucleotide polymorphisms (SNPs) near PNPLA3, NCAN, GCKR, LYPLAL1 and PPP1R3B were associated with NAFLD and with distinctive serum lipid profiles. The present study examined the relevance of these variants to NAFLD in extreme...
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