PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease.

doi:10.1016/j.soard.2014.07.016

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Article

PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery - 1 Jan 2000

Tai Chi-Ming, Huang Chih-Kun, Tu Hung-Pin, Hwang Jau-Chung, Chang Chi-Yang, Yu Ming-Lung

Abstract excerpt

BACKGROUND: The patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 variant is associated with histologic disease severity in patients with nonalcoholic fatty liver disease (NAFLD); however, whether the PNPLA3 genotype has an effect on susceptibility of nonalcoholic steatohepatitis (NASH) from NAFLD among severely obese patients remains unclear. The objective of this study was to investigate...

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PMID: 25240529
DOI: 10.1016/j.soard.2014.07.016

Genes

PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease.PMID 25240529Read ↗

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) susceptibility and severitySemantic proximity Read ↗

Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease.Semantic proximity Read ↗

Interactions of a PPARGC1A Variant and a PNPLA3 Variant Affect Nonalcoholic Steatohepatitis in Severely Obese Taiwanese Patients.Semantic proximity Read ↗

A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease.Semantic proximity Read ↗

Association of single nucleotide polymorphism at PNPLA3 with fatty liver, steatohepatitis, and cirrhosis of liver.Semantic proximity Read ↗

PNPLA3 polymorphisms (rs738409) and non-alcoholic fatty liver disease risk and related phenotypes: a meta-analysis.Semantic proximity Read ↗

Association Between Patatin-Like Phospholipase Domain Containing 3 Gene (PNPLA3) Polymorphisms and Nonalcoholic Fatty Liver Disease: A HuGE Review and Meta-AnalysisSemantic proximity Read ↗

Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.Semantic proximity Read ↗

The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis.Semantic proximity Read ↗

Role of the PNPLA3 I148M polymorphism in nonalcoholic fatty liver disease and fibrosis in Korea.Semantic proximity Read ↗

Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.Semantic proximity Read ↗

Association Between the PNPLA3 rs738409 Polymorphism and Susceptibility to Non-Alcoholic Fatty Liver Disease: A Systematic Review and Ethnicity-Stratified Meta-analysisSemantic proximity Read ↗

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