Article
Establishment of real time allele specific locked nucleic acid quantitative PCR for detection of HBV YIDD (ATT) mutation and evaluation of its application.
PloS one - 1 Jan 2014
Zeng Yongbin, Li Dezhong, Wang Wei, Su Mingkuan, Lin Jinpiao, Chen Huijuan, Jiang Ling, Chen Jing, Yang Bin, Ou Qishui
Abstract excerpt
BACKGROUND: Long-term use of nucleos(t)ide analogues can increase risk of HBV drug-resistance mutations. The rtM204I (ATT coding for isoleucine) is one of the most important resistance mutation sites. Establishing a simple, rapid, reliable and highly sensitive assay to detect the resistant mutants as early as possible is of great clinical significance. METHODS: Recombinant plasmids for HBV YMDD...
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