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Article

Germline HOXB13 G84E mutation carriers and risk to twenty common types of cancer: results from the UK Biobank.

British journal of cancer - 1 Oct 2020

Wei Jun, Shi Zhuqing, Na Rong, Wang Chi-Hsiung, Resurreccion W Kyle, Zheng S Lilly, Hulick Peter J, Cooney Kathleen A, Helfand Brian T, Isaacs William B, Xu Jianfeng

Abstract excerpt

Germline HOXB13 G84E mutation has been consistently associated with prostate cancer (PCa) risk, but its association with other cancers is controversial. We systematically tested its association with the 20 most common cancer types in subjects from the UK Biobank. The G84E mutation was found in 1,545 (0.34%) of 460,224 participants of European ancestry. While mutation status did not associate with cancer risk in...

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PMID: 32830201
DOI: 10.1038/s41416-020-01036-8
PMCID: PMC7591911

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