Article
The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease.
PloS one - 1 Jan 2011
Hector Andreas, Kormann Michael S D, Mack Ines, Latzin Philipp, Casaulta Carmen, Kieninger Elisabeth, Zhou Zhe, Yildirim Ali Ö, Bohla Alexander, Rieber Nikolaus, Kappler Matthias, Koller Barbara, Eber Ernst, Eickmeier Olaf, Zielen Stefan, Eickelberg Oliver, Griese Matthias, Mall Marcus A, Hartl Dominik
Abstract excerpt
The chitinase-like protein YKL-40 was found to be increased in patients with severe asthma and chronic obstructive pulmonary disease (COPD), two disease conditions featuring neutrophilic infiltrates. Based on these studies and a previous report indicating that neutrophils secrete YKL-40, we hypothesized that YKL-40 plays a key role in cystic fibrosis (CF) lung disease, a prototypic neutrophilic disease. The aim...
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