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Article

YKL-40 as a clinical biomarker in adult patients with CF: Implications of a CHI3L1 single nucleotide polymorphism in disease severity.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Nov 2021

Coriati Adèle, Bouvet Guillaume F, Massé Chantal, Ducruet Thierry, Berthiaume Yves

Abstract excerpt

BACKGROUND: YKL-40 (chitinase 3-like 1 gene; CHI3L1) is an inflammatory marker that is increased in the blood of patients with inflammatory diseases, including cystic fibrosis (CF). The objective of our study was to explore the relationship between circulating levels of YKL-40, selected CHI3L1 single nucleotide polymorphisms (SNPs) and the severity of CF disease. METHODS: A prospective cohort of 188 adult...

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PMID: 33277205
DOI: 10.1016/j.jcf.2020.11.011

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