Article
Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.
The Journal of biological chemistry - 10 Jun 2011
Wickham Stephanie E, Hotze Eileen M, Farrand Allison J, Polekhina Galina, Nero Tracy L, Tomlinson Stephen, Parker Michael W, Tweten Rodney K
Abstract excerpt
CD59 is a glycosylphosphatidylinositol-anchored protein that inhibits the assembly of the terminal complement membrane attack complex (MAC) pore, whereas Streptococcus intermedius intermedilysin (ILY), a pore forming cholesterol-dependent cytolysin (CDC), specifically binds to human CD59 (hCD59) to initiate the formation of its pore. The identification of the residues of ILY and hCD59 that form their binding...
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