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Article

Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation

2 Dec 2016

Abstract excerpt

The plasma membrane provides an essential barrier, shielding a cell from the pressures of its external environment. Pore-forming proteins, deployed by both hosts and pathogens alike, breach this barrier to lyse target cells. Intermedilysin is a cholesterol-dependent cytolysin that requires the human immune receptor CD59, in addition to cholesterol, to form giant β-barrel pores in host membranes. Here we integrate...

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PMID: 27910935
DOI: 10.1038/srep38446

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