Article

Generation of dimeric single-chain antibodies neutralizing the cytolytic activity of vaginolysin

2017-07-01

Abstract excerpt

Gardnerella vaginalis is a bacterial vaginosis (BV)-associated vaginal bacterium that produces the toxin vaginolysin (VLY). VLY is a pore-forming toxin that is suggested to be the main virulence factor of G. vaginalis. The high recurrence rate of BV and the emergence of antibiotic-resistant bacterial species demonstrate the need for the development of recombinant antibodies as novel therapeutic agents for disease...

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Literature Corpus work: 964e7386-f161-5f54-b6de-7b62b1a32f55
DOI: 10.1016/j.ejbt.2017.05.003

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