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Article

Knockdown of SKN-1 and the Wnt effector TCF/POP-1 reveals differences in endomesoderm specification in C. briggsae as compared with C. elegans.

Developmental biology - 1 Jan 2009

Lin Katy Tan-Hui, Broitman-Maduro Gina, Hung Wendy W K, Cervantes Serena, Maduro Morris F

Abstract excerpt

In the nematode, C. elegans, the bZIP/homeodomain transcription factor SKN-1 and the Wnt effector TCF/POP-1 are central to the maternal specification of the endomesoderm prior to gastrulation. The 8-cell stage blastomere MS is primarily a mesodermal precursor, giving rise to cells of the pharynx and body muscle among others, while its sister E clonally generates the entire endoderm (gut). In C. elegans, loss of...

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Identifiers

PMID: 18977344
DOI: 10.1016/j.ydbio.2008.10.001
PMCID: PMC2648516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Knockdown of SKN-1 and the Wnt effector TCF/POP-1 reveals differences in endomesoderm specification in C. briggsae as compared with C. elegans.PMID 18977344Read ↗

Roles of the Wnt effector POP-1/TCF in the C. elegans endomesoderm specification gene network.Semantic proximity Read ↗

Maternal deployment of the embryonic SKN-1-->MED-1,2 cell specification pathway in C. elegans.Semantic proximity Read ↗

Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm.Semantic proximity Read ↗

Genetic redundancy in endoderm specification within the genus Caenorhabditis.Semantic proximity Read ↗

POP-1 controls axis formation during early gonadogenesis in C. elegans.Semantic proximity Read ↗

pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos.Semantic proximity Read ↗

Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3beta homolog is mediated by MED-1 and -2 in C. elegans.Semantic proximity Read ↗

Partially compromised specification causes stochastic effects on gut development in C. elegans.Semantic proximity Read ↗

C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity.Semantic proximity Read ↗

sem-4/spalt and egl-17/FGF have a conserved role in sex myoblast specification and migration in P. pacificus and C. elegans.Semantic proximity Read ↗

Distinct functions of three Wnt proteins control mirror-symmetric organogenesis in the C. elegans gonad.Semantic proximity Read ↗

DSH-2 regulates asymmetric cell division in the early C. elegans somatic gonad.Semantic proximity Read ↗

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