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Article

Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm.

Cell - 22 Aug 1997

Thorpe C J, Schlesinger A, Carter J C, Bowerman B

Abstract excerpt

A polarizing signal induces endoderm production by a 4-cell stage blastomere in C. elegans called EMS. We identified 16 mutations in five genes, mom-1 through mom-5, required for EMS to produce endoderm. mom-1, mom-2, and mom-3 are required in the signaling cell, P2, while mom-4 is required in EMS. P2 signaling downregulates an HMG domain protein, POP-1, in one EMS daughter. The sequence of mom-2 predicts that it...

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PMID: 9288749
DOI: 10.1016/s0092-8674(00)80530-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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