Article
Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm.
Cell - 22 Aug 1997
Thorpe C J, Schlesinger A, Carter J C, Bowerman B
Abstract excerpt
A polarizing signal induces endoderm production by a 4-cell stage blastomere in C. elegans called EMS. We identified 16 mutations in five genes, mom-1 through mom-5, required for EMS to produce endoderm. mom-1, mom-2, and mom-3 are required in the signaling cell, P2, while mom-4 is required in EM...
Topics
- Alleles
- Animals
- Blastomeres
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Polarity
- DNA-Binding Proteins
- Down-Regulation
- Embryonic Induction
- Endoderm
- Genes, Helminth
- Glycoproteins
- Helminth Proteins
- High Mobility Group Proteins
- Mesoderm
- Mutation
- Signal Transduction
- Spindle Apparatus