Article
Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations.
The pharmacogenomics journal - 1 Oct 2012
Song K, Nelson M R, Aponte J, Manas E S, Bacanu S-A, Yuan X, Kong X, Cardon L, Mooser V E, Whittaker J C, Waterworth D M
Abstract excerpt
Elevated plasma levels of lipoprotein-associated phospholipase A(2) (Lp-PLA2) activity have been shown to be associated with increased risk of coronary heart disease and an inhibitor of this enzyme is under development for the treatment of that condition. A Val279Phe null allele in this gene, that may influence patient eligibility for treatment, is relatively common in East Asians but has not been observed in...
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