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Article

JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice.

Journal of molecular cell biology - 1 Feb 2015

Zhang Feng, Xu Longyong, Xu Longxia, Xu Qing, Li Dangsheng, Yang Yingzi, Karsenty Gerard, Chen Charlie Degui

Abstract excerpt

JMJD3 (KDM6B) is an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression. However, the function of JMJD3 in vivo is not well understood. Here we show that JMJD3 is highly expressed in cells of the chondrocyte lineage, especially in prehypertrophic and hypertrophic chondrocytes, during endochondral ossification. Homozygous deletion of Jmjd3 results in severely decreased proliferation and...

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Source

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Identifiers

PMID: 25587042
DOI: 10.1093/jmcb/mjv003
PMCID: PMC4342687

Genes

RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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