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Article

Significance of MEF2C and RUNX3 Regulation for Endochondral Differentiation of Human Mesenchymal Progenitor Cells

4 Mar 2020

Abstract excerpt

Guiding progenitor cell development between chondral versus endochondral pathways is still an unachieved task of cartilage neogenesis, and human mesenchymal progenitor cell (MPC) chondrogenesis is considered as a valuable model to better understand hypertrophic development of chondrocytes. Transcription factors Runx2, Runx3 and Mef2c play prominent roles for chondrocyte hypertrophy during mouse development, but...

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PMID: 32195247
DOI: 10.3389/fcell.2020.00081

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