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Article

MEF2C transcription factor controls chondrocyte hypertrophy and bone development.

Developmental cell - 1 Mar 2007

Arnold Michael A, Kim Yuri, Czubryt Michael P, Phan Dillon, McAnally John, Qi Xiaoxia, Shelton John M, Richardson James A, Bassel-Duby Rhonda, Olson Eric N

Abstract excerpt

Chondrocyte hypertrophy is essential for endochondral bone development. Unexpectedly, we discovered that MEF2C, a transcription factor that regulates muscle and cardiovascular development, controls bone development by activating the gene program for chondrocyte hypertrophy. Genetic deletion of Mef2c or expression of a dominant-negative MEF2C mutant in endochondral cartilage impairs hypertrophy, cartilage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17336904
DOI: 10.1016/j.devcel.2007.02.004

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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