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Article

FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.

Nature communications - 14 Jan 2015

Chu Wai Kit, Payne Miranda J, Beli Petra, Hanada Katsuhiro, Choudhary Chunaram, Hickson Ian D

Abstract excerpt

Unscheduled homologous recombination (HR) can lead to genomic instability, which greatly increases the threat of neoplastic transformation in humans. The F-box DNA helicase 1 (FBH1) is a 3'-5' DNA helicase with a putative function as a negative regulator of HR. It is the only known DNA helicase to contain an F-box, suggesting that one of its functions is to act as a ubiquitin ligase as part of an SCF (SKP1, CUL1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25585578
DOI: 10.1038/ncomms6931

Genes

RAD51
FBH1
CUL1
SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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