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Article

FBH1 protects melanocytes from transformation and is deregulated in melanomas.

Cell cycle (Georgetown, Tex.) - 1 Apr 2013

Jeong Yeon-Tae, Cermak Lukas, Guijarro Maria V, Hernando Eva, Pagano Michele

Abstract excerpt

FBH1 is a member of the UvrD family of DNA helicases and plays a crucial role in the response to DNA replication stress. In particular, upon DNA replication stress, FBH1 promotes double-strand breakage and activation of the DNA-PK and ATM signaling cascades in a helicase-dependent manner. In the present manuscript, we show that FBH1 is often deleted or mutated in melanoma cells, which results in their increased...

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Share to DNA Breaks, Double-Stranded
Share to DNA Helicases
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Melanocytes

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Source

Open in PubMed Open full text

Identifiers

PMID: 23466708
DOI: 10.4161/cc.24165
PMCID: PMC3646868

Genes

FBH1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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