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Article

Pre-gating conformational changes in the ChETA variant of channelrhodopsin-2 monitored by nanosecond IR spectroscopy.

Journal of the American Chemical Society - 11 Feb 2015

Lórenz-Fonfría Víctor A, Schultz Bernd-Joachim, Resler Tom, Schlesinger Ramona, Bamann Christian, Bamberg Ernst, Heberle Joachim

Abstract excerpt

Light-gated ion permeation by channelrhodopsin-2 (ChR2) relies on the photoisomerization of the retinal chromophore and the subsequent photocycle, leading to the formation (on-gating) and decay (off-gating) of the conductive state. Here, we have analyzed the photocycle of a fast-cycling ChR2 variant (E123T mutation, also known as ChETA), by time-resolved UV/vis, step-scan FT-IR, and tunable quantum cascade laser...

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PMID: 25584873
DOI: 10.1021/ja5108595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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