Computational screening of one- and two-photon spectrally tuned channelrhodopsin mutants.

Abstract excerpt

Optogenetics is by now a well-established field within neuroscience where neuro-response is controlled at the molecular level using the photochemical properties of channelrhodopsin (ChR). In this study the recently published X-ray structure of retinal inside the ChR binding pocket serves as the basis for conducting high-level polarizable embedding quantum mechanical/molecular mechanical (QM/MM) mutation studies...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mutation
• Share to Photons