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Article

Electrostatic Control of Photoisomerization in Channelrhodopsin 2.

Journal of the American Chemical Society - 14 Apr 2021

Liang Ruibin, Yu Jimmy K, Meisner Jan, Liu Fang, Martinez Todd J

Abstract excerpt

Channelrhodopsin 2 (ChR2) is the most commonly used tool in optogenetics. Because of its faster photocycle compared to wild-type (WT) ChR2, the E123T mutant of ChR2 is a useful optogenetic tool when fast neuronal stimulation is needed. Interestingly, in spite of its faster photocycle, the initial step of the photocycle in E123T (photoisomerization of retinal protonated Schiff base or RPSB) was found...

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Identifiers

PMID: 33794085
DOI: 10.1021/jacs.1c00058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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